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Metabolic levels associated with MTX resistance In addition to the association between metabolic fold change and MTX resistance, we searched for correlations between metabolic concentration and resistance to MTX (expressed as IC50) at 48 and 96 hours in either the presence or absence of the drug ( Table 1 )

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These results indicate that the prodrug nanosystem has excellent safety in plants, aquatic organisms, soil ecosystems, and human cell models, making it a promising candidate for sustainable disease management

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Bioavailability is still low, but it is useful for long-term management as this form is over-the-counter